Ginsberg Lab Publishes in Frontiers in Neuroscience
Dr. Stephen Ginsberg and Ginsberg Lab members (first author Melissa Alldred, Kyrillos Ibrahim, Harshitha Pidikiti, and Sang Han Lee) published their latest work in Frontiers in Neuroscience. The article that appeared in the February 2025 is titled, “Profiling hippocampal neuronal populations reveals unique gene expression mosaics reflective of connectivity-based degeneration in the Ts65Dn mouse model of Down syndrome and Alzheimer’s disease.” Their research results indicate that each population of excitatory hippocampal neurons exhibited unique gene expression alterations in Ts65Dn mice. Bioinformatic inquiry revealed unique vulnerabilities and differences with mechanistic implications coinciding with onset of degeneration in this model of DS/AD, suggesting precision medicine targeting of individual populations of neurons for rational therapeutic development.