Phil Stavrides and Nixon Lab Publish in eLife
First author Phil Stavrides, senior authors Dun-Sheng Yang and Ralph Nixon with Nixon Lab members published their recent findings in eLife. The article titled, “mTOR inhibition in Q175 Huntington’s disease model mice facilitates neuronal autophagy and mutant huntingtin clearance,” showed that administration of a mTOR inhibitor to 6-month-old TRGL/Q175 mice normalized lysosome number, ameliorated aggresome pathology while reducing mHTT-, p62-, and ubiquitin-immunoreactivities, suggesting the beneficial potential of autophagy modulation at early stages of Huntington’s disease progression.