New Nixon Lab Publication Graces Cover of Journal of Neuroscience
First author Ying Jiang, senior authors Paul Mathews and Ralph Nixon and other members of the Nixon Lab published their latest work titled, “Increased Neuronal Expression of the Early Endosomal Adaptor APPL1 Replicates Alzheimer’s Disease-Related Endosomal and Synaptic Dysfunction with Cholinergic Neurodegeneration,” in the July 16th issue of the Journal of Neuroscience. The research shows that neuronal APPL1 elevation modeling its functional increase in the AD brain induces a cascade of AD-related pathological effects within neurons, including early endosome anomalies, synaptic dysfunction, and selective neurodegeneration. This in vivo model highlights the contributions of APPL1 to the pathobiology and neuronal consequences of early endosomal pathway disruption and its potential value as a therapeutic target.
A representative brain image of the mouse model developed by Jiang et al. appears on the cover page of the journal.