Culmination of 8 Years of Research Published in Molecular Psychiatry

New York – The July edition of the online journal, Molecular Biology, contains an open access article which is the culmination of eight years of research from the Nixon Lab at the Center for Dementia Research. The article, which was selected for the cover of the July 21 issue, titled “Evidence that the rab5 effector APPL1 mediates APP-βCTF-induced dysfunction of endosomes in Down syndrome and Alzheimer’s disease,” shows that a missing protein is the earliest known change in Alzheimer’s disease, possibly allowing for further drug therapies to be developed. A press release from EurekAlert!, an online science news service featuring health, medicine, science and technology news from leading research institutions and universities, explains the significance of this research.