News

Dr. Stephen Ginsberg, Research Scientist at the CDR and Associate Professor in the NYU Grossman School of Medicine Department of Psychiatry, Department of Neuroscience and Physiology, and the NYU Neuroscience Institute, describes the focus of the Ginsberg Laboratory is to delineate cellular and molecular mechanisms underlying neurodevelopmental and neurodegenerative disorders. His most recent work titled, “Targeting stressor-induced dysfunctions in protein–protein interaction networks via epichaperomes,” featured on the cover of the January issue of Trends in Pharmacological Sciences, suggests that stressor-induced dysfunctions in protein-protein interaction networks may be targeted via structures called epichaperomes. Ginsberg hypothesizes that the disease network – a map of how individual or a combination of stressors alter cellular PPIs, and in turn perturb the system – is a target for therapeutic intervention. A paradigm shift in developing therapies is needed that requires movement from the unitary protein approach to the goal of targeting context-specific PPI network dysfunctions for disease control.