Lisgaras Coauthors Two Papers in Alzheimer’s and Dementia
Dr. Christos Lisgaras, collaborating with researchers from New York University and the Sant Pau Memory clinic in Barcelona, has published two significant studies in July 2025 in Alzheimer’s and Dementia: The Journal of the Alzheimer’s Association, an open access journal.
The first study, titled “High-frequency oscillations >250 Hz in people with Down syndrome and associated Alzheimer’s disease dementia,” focuses on high-frequency oscillations (HFOs) in individuals with Down syndrome (DS). People with DS carry a high risk of developing Alzheimer’s disease (AD). The study found that these HFOs could be detected non-invasively and before the onset of clinical dementia symptoms. This suggests HFOs may serve as an early biomarker for predicting AD dementia in adults with DS.
The second study, titled “Impact of Alzheimer’s disease on sleep in adults with Down syndrome,” investigates how sleep changes as individuals with DS progress along the Alzheimer’s disease continuum. The study found that 1) DS is associated with increased slow-wave sleep (SWS) and reduced rapid eye movement (REM) sleep; 2) age-related decreases in SWS and REM sleep are accelerated in DS; 3) Obstructive sleep apnea prevalence increases along the Alzheimer’s disease continuum in DS.