New CDR Paper in Journal of Neuroscience

New York – A paper from Aidong Yuan and Ralph Nixon titled “Peripherin Is a Subunit of Peripheral Nerve Neurofilaments: Implications for Differential Vulnerability of CNS and PNS Axons, ” is published in the June issue of Journal of Neuroscience.  This latest research from members of the CDR shows that peripherin and the neurofilament proteins are functionally interdependent. The results strongly support the view that rather than forming an independent structure, peripherin is a subunit of neurofilaments in the adult PNS. These findings provide a basis for its close relationship with neurofilaments in PNS diseases associated with neurofilament accumulation.