Nixon Lab Releases New Paper on Autophagy Failure in AD

New York – A new paper by the Nixon lab, headed by CDR Director Ralph Nixon,  titled “Autophagy failure in Alzheimer’s disease and the role of defective lysosomal acidification,” makes its first appearance on pages 1949–1961 of Volume 37, Issue 12 of a Special Issue of The Neurobiology of Aging and Alzheimer’s Disease.  The Nixon lab research evaluates the most commonly used pH probes and review evidence that lysosomal acidification is defective in Alzheimer’s disease (AD), extending the Lab’s original findings of elevated lysosomal pH in presenilin 1 knockout cells.