Open Access Journal, Biomolecules, Includes Piece by Ginsberg Lab
First author Dr. Melissa Alldred and Ginsberg Lab members published a research article, titled “Benefits of Maternal Choline Supplementation on Aged Basal Forebrain Cholinergic Neurons (BFCNs) in a Mouse Model of Down Syndrome and Alzheimer’s Disease” in the August issue of Biomolecules, an international, peer-reviewed, open access journal. The study finds that maternal choline supplementation (MCS) attenuates selected dysregulated differentially expressed genes and relevant pathways in aged BFCNs. Trisomic MCS-responsive improvements included pathways such as cognitive impairment and nicotinamide adenine dinucleotide signaling, among others, indicative of increased behavioral and bioenergetic fitness. Although MCS does not eliminate the DS/AD phenotype, early choline delivery provides long-lasting benefits to aged trisomic BFCNs, indicating that MCS prolongs neuronal health in the context of DS/AD.