Paul Mathews and Ralph Nixon Co-author Paper Appearing in Brain

New York – The article, “Neurofilaments: neurobiological foundations for biomarker applications,” co-authored by two CDR researchers, Paul Mathews and Ralph Nixon, and others, appears in the May 14, 2020 edition of Brain. In the article, the researchers discuss how they will review the neurobiology of neurofilament proteins, explore emerging understanding of the mechanisms of neurofilament degradation and clearance, as well as review new methods for future elucidation of the kinetics of their turnover in humans. Primary roles of neurofilaments in the pathogenesis of human diseases are also described.