Report by Amanda Labuza and CDR Members Appears in Brain Sciences
Research from first author Amanda Labuza, with senior authors Paul Mathews and Stephen Ginsberg, along with lab members Harshitha Pidikiti, Melissa Alldred, Kyrillos Ibrahim, Katherine Peng, and Jonathan Pasato, appears in the October 17, 2025 edition of Brain Sciences. The article titled, “Aging, Rather than Genotype, Is the Principal Contributor to Differential Gene Expression Within Targeted Replacement APOE2, APOE3, and APOE4 Mouse Brain,” concludes that transcriptomic results suggest that the most significant impact on brain-level expression changes in humanized APOE mice is aging and that APOE4 exacerbates this process.