Scharfman Co-authors Paper and Provides Perspective

New York – A recent publication in Science, titled “Adult-born hippocampal neurons bidirectionally modulate entorhinal inputs into the dentate gyrus,” co-authored by Dr. Helen Scharfman of the CDR, examines the role of adult neurogenesis in hippocampal brain circuitry. The authors found that adult-born neurons either inhibited or excited the dentate gyrus, depending on whether synaptic inputs originated from the lateral or the medial entorhinal cortex. The action of adult-born neurons depended on the demands of the environment, which alters cortical and subcortical input to the dentate gyrus. A Perspective article in the same issue provides additional context.