Scharfman Lab Review in Frontiers in Dementia
An open access review by Helen Scharfman, Christos Lisgaras, Stephen Ginsberg, and former members of the Scharfman Lab appears in Frontiers in Dementia. The article titled, “Evidence that cholinergic mechanisms contribute to hyperexcitability at early stages in Alzheimer’s disease,” reviewed the effects of a prenatal diet that increases choline, the precursor to acetylcholine and modulator of many other functions. In mouse models of AD, maternal choline supplementation reduces medial septal cholinergic pathology, amyloid accumulation and hyperexcitability, especially in the dentate gyrus, and improves cognition.