Ying Jiang, Ph.D.
Principal Investigator

Research Scientist, Center for Dementia Research

Ph.D. Binghamton University

Postdoctoral Training
Center for Dementia Research, Nathan Kline Institute, Orangeburg, NY

Research Interests
My primary research interests focus on the pathogenesis of various neurodegenerative diseases. I have employed several mouse models, including Down syndrome, amyloid precursor protein (APP), Rab5 and APPL1 transgenic mouse models to investigate the mechanism by which dysfunction of neuronal endosomal-lysosomal system influences Alzheimer’s disease onset.

  • Defined the role of amyloid precursor protein (APP) metabolite, APP-βCTF, in the dysfunction of the endosomal and lysosomal system using Down Syndrome fibroblasts from human patients and Down Syndrome mouse models.
  • Discovered that partial reduction of BACE1 expression can rescue Alzheimer’s Disease-related endosomal anomalies and cholinergic neurodegeneration using the Down Syndrome mouse model.
  • Collaborated with pharmaceutical companies to assess the effect of p38 inhibition on Rab5 activation and its impact on Alzheimer’s Disease using cell lines and mouse models.
  • Investigated the cellular and molecular mechanisms of a specific p38α inhibitor used in the ongoing clinical trial for both Alzheimer’s Disease and Mild-to-Moderate Dementia with Lewy bodies, which showed promising results in the Phase 2 AscenD-LB study.
  • Developed new ELISA to detect Aβ and APP-βCTF for various cell types and mouse brain tissues.

All publications